Genetics & Biology · The Living Address · Paper 16 of 23

Mating-Type Regulation in Yeast

The Loaded Address

The loaded address · carries all, expresses one · combinatorial a1/α1/α2 · related to the homeobox

Stephen Daubney · The Daubney Foundation

carries a and α, expresses onecassette copied into MATa1 · α1 · α2 combinatorialkin to the homeobox (Paper 17)

The biology

Yeast has three cell types — haploid a, haploid α, and diploid a/α. A haploid cell carries both a and α information but expresses only one, and can switch by copying a silent stored cassette into the active MAT slot. A small set of regulators — a1, α1, α2 — acts combinatorially to specify the three states.

An address that carries all and reads one

This is a loaded address: the cell holds the whole coordinate — both identities — but expresses only the one in the active slot, and can rewrite that slot from its silent store. Identity is not fixed in the sequence but selected from it, and a handful of regulators reading in combination pick which state the cell is in. The regulator that does this is kin to the homeobox that lays out an animal body (Paper 17) — the same combinatorial address-reading, one register down.

THE READING
The cell carries the full address and expresses one reading of it; switching rewrites the active slot from a silent store — identity selected from a coordinate the cell holds in whole.

Where this departs from current science

Current science saysThe Force of Time says
Mating-type switching is cassette gene conversion.It is a loaded address — the cell carries all, reads one, and rewrites the active slot from its store.
a1/α1/α2 form a combinatorial regulatory logic.They are combinatorial address-reading, kin to the homeobox one register up.

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The same single substance — time — writes the address of a cell, the wavelength of a spectral line, and the orbit of a planet. If this stirred your curiosity, the whole weave is waiting.

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