Genetics & Biology · The Living Address · Paper 19 of 23

Transposable Genetic Elements: The Mobile Registry

The Restless Registry

The mobile registry · elements that copy into new places · McClintock · parasite or evolution's tool

Stephen Daubney · The Daubney Foundation

transposons = mobile addressescopy into new locationsubiquitous, from maize to humanheld in check by selection

The biology

Transposons are DNA sequences that copy themselves into new chromosomal locations, found by McClintock in maize and ubiquitous from bacteria to humans. They can be read as parasitic — a burden on replication, able to damage genes — yet the book stresses their value: repeated sequences facilitate chromosome rearrangements and may greatly speed evolution. A deeper question is why such sequences do not come to make up most of a genome; selection against carrying too much unused sequence holds them in check.

A registry that will not sit still

In the reading of this book the genome is a registry of addresses, and the transposon is a coordinate that moves — copying itself to new places in the map. This is the address space in motion: not the fixed lattice of a body plan but a restless part of the registry, edited and reshuffled, held within bounds by the cost of carrying too much. That such mobility can speed evolution is the registry rewriting itself, exploring new arrangements of the coordinate.

THE READING
A transposon is a mobile coordinate — a piece of the address space that copies itself to new locations, reshuffling the registry within the bounds selection allows.

Where this departs from current science

Current science saysThe Force of Time says
Transposons are selfish/parasitic DNA, tolerated or exploited.They are mobile coordinates — the address space in motion, reshuffling the registry.
Their spread is limited by fitness cost.The registry is held within bounds by the cost of carrying too much unused coordinate.

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This paper, and any information drawn from it, may be used freely provided the reference attribution to Stephen Daubney and The Daubney Foundation is recognised.

The same single substance — time — writes the address of a cell, the wavelength of a spectral line, and the orbit of a planet. If this stirred your curiosity, the whole weave is waiting.

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